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Long Research Lab

Department of Pharmaceutical Sciences, School of Pharmacy

Publications

  1. Long, T.E., Naidu S.T.‡, Hissom E.G.‡, Meka Y.‡, Chavva H., Brown K.C., Valentine M.E., Fan J., Denvir J., Primerano D.A., Yu H.D., Valentovic M.A. Disulfiram induces redox imbalance and perturbations in central glucose catabolism and metal homeostasis to inhibit the growth of Staphylococcus aureus. Sci Rep. 2025, 15, 15658. https://doi.org/10.1038/s41598-025-00078-3 link
  2. Evans S.E.‡; Valentine M.E.; Gallimore F.; Meka Y.‡; Koehler S.I.; Yu H.D.; Valentovic M.A.; Long T.E.* “Perturbations in the Gut Microbiome of C57BL/6 Mice by the Sobriety Aid Antabuse® (Disulfiram),”. J Appl Microbiol. 2025, 136, 1:lxae305. link
  3. Harrison S.; Verratti K.; Long T.E.; Meka Y.‡; Greytak E.M.; Necciai B.; Sozhamannan S.; Sparklin R.* Draft genome assemblies of ciprofloxacin-resistant derivatives of Bacillus cereus strain ATCC14579. Microbiol Resour Announc. 2025, 0:e00100-25.https://doi.org/10.1128/mra.00100-25
  4. Chavva H.; Meka Y.‡; Long T.E.* “Antimicrobial Pharmacodynamics of Vancomycin and Disulfiram (Antabuse®) in Staphylococcus aureus,” Front. Microbiol. 2023, 13:1092257. link
  5. Blume L.; Long T.E.; Turos E.* “Applications and Opportunities in Using Disulfides, Thiosulfinates, and Thiosulfonates as Antibacterials.” Int J Mol Sci. 2023, 24, 8659. link
  6. Newton E..; Starcovic S.A.; Menze M.; Konkle M.E.; Long T.E.; Hazlehurst L.A.; Huber J.D.; Robart A.R.; Geldenhuys W.J.* “Development of a Fluorescence Screening Assay for Binding Partners of the Iron-sulfur Mitochondrial Protein MitoNEET,” Bioorg Med Chem Lett. 2023, 89:129310. link
  7. Brown, K.C.; Modi, K.J., Light, R.S.; Cox, A.J.; Long, T.E.; Gadepalli, R.S.; Rimoldi, J.M.; Miles, S.L.; Rankin, G.; Valentovic, M.; Denning, K.L.; Tirona, M.T.; Finch, P.T.; Hess, J.A.; Dasgupta, P.* “Anticancer Activity of Region B Capsaicin Analogs,” J Med Chem. 2023, 66, 7, 4294–4323. link
  8. Shanholtzer, C.N.†‡; Rice, C.†; Watson, K.†; Carreon ,H.†; Long, T.E.* “Effect of Copper on the Antifungal Activity of Disulfiram (Antabuse®) in Fluconazole-resistant Candida Strains,” Med. Mycol. 2022, 60, myac016. link
  9. Adeluola, A.A.‡; Bosomtwe, N.; Long, T.E.; Amin, A.R.M. R.* “Context-dependent Activation of p53 Target Genes and Induction of Apoptosis by Actinomycin D in Aerodigestive Tract Cancers,” Apoptosis, 2022, 27, 342–353. link
  10. Lewis, A.D.†; Riedel, T.M.†; Kesler, M.B.A.†; Varney, M.E.; Long, T.E.* “Pharmacological Evaluation of Disulfiram Analogs as Antimicrobial Agents and Their Application as Inhibitors of FosB-Mediated Fosfomycin Resistance,” J. Antibiot. 2022, 75, 146–154. link
  11. Custodio, M.; Sparks, J.; Long, T.E.* “Disulfiram: A Repurposed Drug in Preclinical and Clinical Development for the Treatment of Infectious Diseases,” Anti-Infect. Agents 2022, 20, 34–45. link
  12. Clay, T.B.*; Orwig, K.W.; Stevens, R. A.†; Davis, E.P.†; Jennings, T.M.†; Long, T.E.; Riley, B.L.; Hambuchen, M.B. “Correlation of MRSA Polymerase Chain Reaction (PCR) Wound Swab Testing and Wound Cultures in Skin and Soft Tissue Infections,” Diagn. Microbiol. Infect. Dis. 2021, 100, 115389. link
  13. Cabal, M.-P.*; Long, T.E.; Turos E.; García, A.-B.; Allen. J.L.; Budny, B.G.; Shaw, L.N. “Spiropiperidyl Rifabutins: Expanded In Vitro Testing Against ESKAPE Pathogens and Select Bacterial Biofilms,” J. Antibiot. 2020, 868–872. link
  14. Moore, J.A.†; Meakin, M.†; Earl, M.A.†; Kummer, T.M.†; McAleer, J.M.; Long, T.E.* “Effects of Caspofungin, Tolcapone, and Other FDA-Approved Medications on MRSA Susceptibility to Vancomycin,” J. Glob. Antimicrob. Resist. 2020, 22, 283–289. link
  15. Valentine, M.; Kirby, B.; Withers, T.R.; Johnson, S L.; Long, T.E.; Hao, Y.; Lam, J.; Niles, R.; Yu, H.* “Generation of a Highly Attenuated Strain of Pseudomonas aeruginosa for Commercial Production of Alginate,” Microb. Biotechnol. 2020, 13, 162–175. link
  16. Geldenhuys, W.J.*; Long, T.E.; Saralkar, P.; Iwasaki, T.; Nuñez, R.A.; Nair, R.R.; Konkle, M.E.; Menze, M.A.; Pinti, M.V.; Hollander, J.M.; Hazlehurst, L.A.;  Robart, A.R.* “Crystal Structure of the Mitochondrial Protein MitoNEET Bound to a Benze-sulfonide Ligand,” Commun. Chem. 2019, 2, doi:10.1038/s42004-019-0172-x. link
  17. Kirby, B.; Ahmar, R.A.; Withers, T.R.; Valentine, M.; Valentovic, M.; Long, T.E.; Gaskins, J.; Yu, H.* “Efficacy of Aerosolized Rifaximin Versus Tobramycin for the Treatment of Pseudomonas aeruginosa Pneumonia in Mice,” Antimicrob. Agents Chemother. 2019, 63, pii: e02341–18; doi: 10.1128/AAC.02341-18. link
  18. Geldenhuys, W.J.*; Skolik, R.; Konkle, M.E.; Menze, M.A.; Long, T.E.; Robart, A.E.* “Binding of Thiazolidinediones to the Endoplasmic Reticulum Protein Nutrient-Autophagy Factor 1,” Bioorg. Med. Chem. Lett. 2019, 29, 901–904. link
  19. Frazier, K.R.†; Moore, J.A.†; Long, T.E.* “Antibacterial Activity of Disulfiram and its Metabolites,” J. Applied Microbiol. 2019, 126, 79–86. link
  20. Sheppard, J.G.†; Frazier, K.R.†; Saralkar, P.; Hossain, M.F.; Geldenhuy,s W.; Long, T.E.* “Disulfiram-based Disulfides as Narrow-spectrum Antibacterial Agents,” Bioorg. Med. Chem. Lett. 2018, 28, 1298–1302. link
  21. Sheppard, J.G.†; McAleer, J.P.; Saralkar, P.; Geldenhuys, W.J.; Long, T.E.* “Allicin-inspired Pyridyl Disulfides as Antimicrobial Agents for Multidrug-resistant Staphylococcus aureus,” Eur. J. Med. Chem. 2018, 143, 1185–1195. link
  22. Long T.E.* “Repurposing Thiram and Disulfiram as Antibacterial Agents for Multi-drug Resistant Staphylococcus aureus Infections”. Antimicrob. Agents Chemother. 2017, 61:e00898-17. link
  23. Sheppard, J.G.†; Long, T.E.* “Allicin-Inspired Thiolated Fluoroquinolones as Antibacterials Against ESKAPE Pathogens,” Bioorg. Med. Chem. Lett. 2016, 26,5545–5549. link
  24. Slayton, E.T.†; Hay, A.S.; Babcock, C K.; Long, T.E.* “New Antibiotics in Clinical Trials for Clostridium Difficile,” Expert Rev. Anti. Infect. Ther. 2016, 14, 789–800. link
  25. Long, T.E.*; Keding, L.C.‡; Lewis, D.†; Anstead, M.I.; Withers, T.R.; Yu, H.D. “Anionic Fluoroquinolones as Antibacterials Against Biofilm-producing Pseudomonas aeruginosa,” Bioorg. Med. Chem. Lett. 2016, 26, 1305–1309. link
  26. Long, T.E.*; Williams, J. “Cephalosporins Currently in Early Clinical trials for the Treatment of Bacterial Infections,” Expert Opin. Investig. Drugs 2014, 23, 1375–1387. link
  27. Lu, X.‡; Altharawi, A.‡; Gut, J.; Rosenthal, P.J.; Long, T.E.* “1,4-Naphthoquinone Cations as Antiplasmodial Agents: Hydroxy-, Acyloxy-, and Alkoxy-Substituted Analogs,” ACS Med. Chem. Lett. 2012, 3, 1029–1033. link
  28. Lu, X.‡; Altharawi, A.‡; Hansen, E.N. †; Long, T.E.* “Phase-Transfer Catalysts in the O-Alkylation of 2-Hydroxynaphthoquinones,” Synthesis 2012, 44, 3225–3230. link
  29. Mock, J.‡; N; Taliaferro, J.P.; Lu, X.‡; Patel, S.K.‡; Cummings, B.S.; Long, T.E.* “Haloenol Pyranones and Morpholinones as Antineoplastic Agents of Prostate Cancer,” Bioorg. Med. Chem. Lett. 2012, 22 4854–4858. link
  30. Long, T.E.; Lu, X.‡; Galizzi, M.; Docampo, R.; Gut, J.; Rosenthal, P.J. “Phosphonium Lipocations as Antiparasitic Agents,” Bioorg. Med. Chem. Lett. 2012, 22, 2976–2979. link
  31. Lu, X.‡; Long, T. E.* “Asymmetric Synthesis of Monocyclic β-Lactams from L-Cysteine Using Photochemistry,” Tetrahedron Lett. 2011, 52, 5051–5054. link
  32. Lu, X.‡; Long, T.E.* “o-Nitrophenyl Sulfoxides: Efficient Precursors for the Mild Preparation of Alkenes,” J. Org. Chem. 2010, 75, 249–252. link
  33. Patel, S.K.‡; Long, T.E.* “Preparation of Vinylglycines by Thermolysis of Homocysteine Sulfoxides,” Tetrahedron Lett. 2009, 50, 5067–5070. link
  • † Pharm.D. student       
  • ‡ B.S., M.S., or Ph.D. student
  • * Corresponding author        
From Ph.D. and Postdoctoral Studies
  1. Wencewicz, T.A.; Long, T.E.; Möllmann, U.; Miller, M.J.* “Trihydroxamate Siderophore Fluoroquinolone Conjugates are Selective Sideromycin Antibiotics that Target Staphylococcus aureus,” Bioconjugate Chem. 2013, 24, 473–486. link
  2. Wencewicz, T.A.; Möllmann, U.; Long, T.E.; Miller, M.J.* “Is Drug Release Necessary for Antimicrobial Activity of Siderophore-drug Conjugates? Syntheses and Biological Studies of the Naturally Occurring Salmycin “Trojan Horse” Antibiotics and Synthetic Desferridanoxamine-antibiotic Conjugates,” Biometals 2009, 22, 633–648. link
  3. Chen, D; Falsetti, S.C.; Frezza, M.; Milacic, V.; Kazi, A.; Cui, Q.C; Long, T.E.; Turos, E.; Dou, Q.* “Anti-tumor Activity of N-Thiolated β-Lactam Antibiotics,” Cancer Lett. 2008, 268, 63–69. link
  4. Revell, K.D.; Heldreth, B.; Long T.E.; Jang, S.; Turos, E.* “N-Thiolated β-Lactams: Studies on the Mode of Action and Identification of a Primary Cellular Target in Staphylococcus aureus,” Bioorg. Med. Chem. 2007, 15, 2453–2467. link
  5. Turos, E.*; Long, T.E.; Heldreth B.; Leslie, J.M.; Reddy, G.S.K.; Wang. Y.; Coates, C.; Konaklieva, M.; Dickey, S.; Lim, D.V.; Gonzalez, A.E.“N-Thiolated β-Lactams: A New Family of Anti-Bacillus Agents,” Bioorg. Med. Chem. Lett. 2006, 16, 2084–2090. link
  6. Heldreth B; Long T. E.; Jang, S.; Reddy, G.; Turos, E.*; Dickey, S.; Lim, D.V. “N-Thiolated β-Lactam Antibacterials: Effects of the N-Organothio Substituent on Anti-MRSA Activity,” Bioorg Med Chem. 2006, 14, 3775–3784. link
  7. Turos, E.*; Coates, C.M.; Shim, J.-Y.; Wang, Y.; Leslie J.M.; Long T. E.; Reddy, G.S.K.; Ortiz, A.; Culbreath, M.; Dickey, S.; Lim, D.V.; Alonso, E.; Gonzalez, J. “N-Methylthio β-Lactam Antibacterials: Effects of the C3/C4 Ring Substituents on Anti-MRSA Activity,” Bioorg. Med. Chem. 2005, 13, 6289–6308. link
  8. Kazi, A.; Hill, R.; Long, T.E.; Kuhn, D.J.; Turos, E.; Dou, Q.* “Novel N-Thiolated β-Lactam Antibiotics Selectively Induce Apoptosis in Human Tumor and Transformed, But Not Normal or Nontransformed cells,” Biochem. Pharmacol. 2004, 67, 365–374. link
  9. Carr, J.A.; Al-Azemi, T.F.; Long, T.E.; Shim, J.-Y.; Coates, C.M.; Turos, E.; Bisht, K.S.* “Lipase-Catalyzed Resolution of 4-Aryl-Substituted β-Lactams: Effect of Substitution on the 4-Aryl Ring,” Tetrahedron 2003, 59, 9147–9160. link
  10. Long, T.E.; Turos, E.*; Konaklieva, M.; Blum, A.L.; Amry, A.; Baker, E.A.; Suwandi, L.S.; McCain, M.D.; Rahman, M.; Dickey,S.; Lim, D.V. “Effect of Aryl Ring Fluorination on the Antibacterial Properties of C4 Aryl-Substituted N-Methylthio β-Lactams,” Bioorg. Med. Chem. 2003, 11, 1859–1863. link
  11. Long, T.E.* “Recent Progress Toward the Clinical Development of New Anti-MRSA Antibiotics,” IDrugs 2003, 6, 351–359. link
  12. Coates, C.; Long, T.E.; Turos, E*.; Dickey, S.; Lim, D.V. “N-Thiolated β-lactam Antibacterials: Defining the Role of Unsaturation in the C4 Side Chain,” Bioorg. Med. Chem. 2003, 11,193–196. link
  13. Smith, D.M.; Kazi, A.; Smith, L.; Long, T.E.; Heldreth, B.; Turos, E.; Dou, Q.P.* “A Novel β-Lactam Antibiotic Activates Tumor Cell Apoptotic Program by Inducing DNA Damage,” Mol. Pharmacol. 2002, 61, 1348–1358. link
  14. Turos, E.*; Long, T.E.; Konaklieva, M.I.; Coates, C.; Shim J.-Y.; Dickey, S.; Lim, D.V.; Cannons, A. “N-Thiolated β-Lactams: Novel Antibacterial Agents for Methicillin-Resistant Staphylococcus aureus,” Bioorg. Med. Chem. Lett. 2002, 12, 2229–2223. link
  15. Long, T.E.; Turos, E.* “N-Thiolated β-Lactams,” Curr. Med. Chem.: Anti-Infective Agents 2002, 1, 251–268. link
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