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Long Research Lab

Department of Pharmaceutical Sciences, School of Pharmacy

Publications

  1. Chavva H.; Meka Y.‡; and Long T.E.* “Antimicrobial Pharmacodynamics of Vancomycin and Disulfiram (Antabuse®) in Staphylococcus aureus,” Front. Microbiol. 2023, 13:1092257. link
  2. Blume L.; Long T.E.; Turos E.* “Applications and Opportunities in Using Disulfides, Thiosulfinates, and Thiosulfonates as Antibacterials.” Int J Mol Sci. 2023, 24, 8659. link
  3. Newton E..; Starcovic S.A.; Menze M.; Konkle M.E.; Long T.E.; Hazlehurst L.A.; Huber J.D.; Robart A.R.; Geldenhuys W.J.* “Development of a Fluorescence Screening Assay for Binding Partners of the Iron-sulfur Mitochondrial Protein MitoNEET,” Bioorg Med Chem Lett. 2023, 89:129310. link
  4. Brown K.C.; Modi K.J., Light R.S.; Cox A.J.; Long T.E.; Gadepalli R.S.; Rimoldi J.M.; Miles S.L.; Rankin G.; Valentovic M.; Denning K.L.; Tirona M.T.; Finch P.T.; Hess J.A.; Dasgupta P.* “Anticancer Activity of Region B Capsaicin Analogs,” J Med Chem. 2023, 66, 7, 4294–4323. link
  5. Shanholtzer C. N.†‡; Rice C.†; Watson, K.†; Carreon H.†; Long T. E.* “Effect of Copper on the Antifungal Activity of Disulfiram (Antabuse®) in Fluconazole-resistant Candida Strains,” Med. Mycol. 2022, 60, myac016. link
  6. Adeluola, A.A.‡; Bosomtwe, N.; Long, T.E.; Amin, A.R.M. R.* “Context-dependent Activation of p53 Target Genes and Induction of Apoptosis by Actinomycin D in Aerodigestive Tract Cancers,” Apoptosis, 2022, 27, 342–353. link
  7. Lewis, A.D.†; Riedel, T.M.†; Kesler, M.B.A.†; Varney, M.E.; Long, T.E.* “Pharmacological Evaluation of Disulfiram Analogs as Antimicrobial Agents and Their Application as Inhibitors of FosB-Mediated Fosfomycin Resistance,” J. Antibiot. 2022, 75, 146–154. link
  8. Custodio, M.; Sparks, J.; Long, T.E.* “Disulfiram: A Repurposed Drug in Preclinical and Clinical Development for the Treatment of Infectious Diseases,” Anti-Infect. Agents 2022, 20, 34–45. link
  9. Clay, T.B.*; Orwig, K.W.; Stevens, R. A.†; Davis, E.P.†; Jennings, T.M.†; Long, T.E.; Riley, B.L.; Hambuchen, M.B. “Correlation of MRSA Polymerase Chain Reaction (PCR) Wound Swab Testing and Wound Cultures in Skin and Soft Tissue Infections,” Diagn. Microbiol. Infect. Dis. 2021, 100, 115389. link
  10. Cabal, M.-P.*; Long, T.E.; Turos E.; García, A.-B.; Allen. J.L.; Budny, B.G.; Shaw, L.N. “Spiropiperidyl Rifabutins: Expanded In Vitro Testing Against ESKAPE Pathogens and Select Bacterial Biofilms,” J. Antibiot. 2020, 868–872. link
  11. Moore, J.A.†; Meakin, M.†; Earl, M.A.†; Kummer, T.M.†; McAleer, J.M.; Long, T.E.* “Effects of Caspofungin, Tolcapone, and Other FDA-Approved Medications on MRSA Susceptibility to Vancomycin,” J. Glob. Antimicrob. Resist. 2020, 22, 283–289. link
  12. Valentine, M.; Kirby, B.; Withers, T.R.; Johnson, S L.; Long, T.E.; Hao, Y.; Lam, J.; Niles, R.; Yu, H.* “Generation of a Highly Attenuated Strain of Pseudomonas aeruginosa for Commercial Production of Alginate,” Microb. Biotechnol. 2020, 13, 162–175. link
  13. Geldenhuys, W.J.*; Long, T.E.; Saralkar, P.; Iwasaki, T.; Nuñez, R.A.; Nair, R.R.; Konkle, M.E.; Menze, M.A.; Pinti, M.V.; Hollander, J.M.; Hazlehurst, L.A.;  Robart, A.R.* “Crystal Structure of the Mitochondrial Protein MitoNEET Bound to a Benze-sulfonide Ligand,” Commun. Chem. 2019, 2, doi:10.1038/s42004-019-0172-x. link
  14. Kirby, B.; Ahmar, R.A.; Withers, T.R.; Valentine, M.; Valentovic, M.; Long, T.E.; Gaskins, J.; Yu, H.* “Efficacy of Aerosolized Rifaximin Versus Tobramycin for the Treatment of Pseudomonas aeruginosa Pneumonia in Mice,” Antimicrob. Agents Chemother. 2019, 63, pii: e02341–18; doi: 10.1128/AAC.02341-18. link
  15. Geldenhuys, W.J.*; Skolik, R.; Konkle, M.E.; Menze, M.A.; Long, T.E.; Robart, A.E.* “Binding of Thiazolidinediones to the Endoplasmic Reticulum Protein Nutrient-Autophagy Factor 1,” Bioorg. Med. Chem. Lett. 2019, 29, 901–904. link
  16. Frazier, K. R.†; Moore, J. A.†; Long T. E.* “Antibacterial Activity of Disulfiram and its Metabolites,” J. Applied Microbiol. 2019, 126, 79–86. link
  17. Sheppard, J. G.†; Frazier, K. R.†; Saralkar, P.; Hossain, M. F.; Geldenhuys W. J.; Long T. E.* “Disulfiram-based Disulfides as Narrow-spectrum Antibacterial Agents,” Bioorg. Med. Chem. Lett. 2018, 28, 1298–1302. link
  18. Sheppard, J. G.†; McAleer, J. P.; Saralkar, P.; Geldenhuys, W. J.; Long, T. E.* “Allicin-inspired Pyridyl Disulfides as Antimicrobial Agents for Multidrug-resistant Staphylococcus aureus,” Eur. J. Med. Chem. 2018, 143, 1185–1195. link
  19. Long T.E.* “Repurposing Thiram and Disulfiram as Antibacterial Agents for Multi-drug Resistant Staphylococcus aureus Infections”. Antimicrob. Agents Chemother. 2017, 61:e00898-17. link
  20. Sheppard, J.G.†; Long, T.E.* “Allicin-Inspired Thiolated Fluoroquinolones as Antibacterials Against ESKAPE Pathogens,” Bioorg. Med. Chem. Lett. 2016, 26,5545–5549. link
  21. Slayton, E.T.†; Hay, A.S.; Babcock, C K.; Long, T.E.* “New Antibiotics in Clinical Trials for Clostridium Difficile,” Expert Rev. Anti. Infect. Ther. 2016, 14, 789–800. link
  22. Long, T.E.*; Keding, L.C.‡; Lewis, D.†; Anstead, M.I.; Withers, T.R.; Yu, H.D. “Anionic Fluoroquinolones as Antibacterials Against Biofilm-producing Pseudomonas aeruginosa,” Bioorg. Med. Chem. Lett. 2016, 26, 1305–1309. link
  23. Long, T.E.*; Williams, J. “Cephalosporins Currently in Early Clinical trials for the Treatment of Bacterial Infections,” Expert Opin. Investig. Drugs 2014, 23, 1375–1387. link
  24. Lu, X.‡; Altharawi, A.‡; Gut, J.; Rosenthal, P.J.; Long, T.E.* “1,4-Naphthoquinone Cations as Antiplasmodial Agents: Hydroxy-, Acyloxy-, and Alkoxy-Substituted Analogs,” ACS Med. Chem. Lett. 2012, 3, 1029–1033. link
  25. Lu, X.‡; Altharawi, A.‡; Hansen, E.N. †; Long, T.E.* “Phase-Transfer Catalysts in the O-Alkylation of 2-Hydroxynaphthoquinones,” Synthesis 2012, 44, 3225–3230. link
  26. Mock, J.‡; N; Taliaferro, J.P.; Lu, X.‡; Patel, S.K.‡; Cummings, B.S.; Long, T.E.* “Haloenol Pyranones and Morpholinones as Antineoplastic Agents of Prostate Cancer,” Bioorg. Med. Chem. Lett. 2012, 22 4854–4858. link
  27. Long, T.E.; Lu, X.‡; Galizzi, M.; Docampo, R.; Gut, J.; Rosenthal, P.J. “Phosphonium Lipocations as Antiparasitic Agents,” Bioorg. Med. Chem. Lett. 2012, 22, 2976–2979. link
  28. Lu, X.‡; Long, T. E.* “Asymmetric Synthesis of Monocyclic β-Lactams from L-Cysteine Using Photochemistry,” Tetrahedron Lett. 2011, 52, 5051–5054. link
  29. Lu, X.‡; Long, T.E.* “o-Nitrophenyl Sulfoxides: Efficient Precursors for the Mild Preparation of Alkenes,” J. Org. Chem. 2010, 75, 249–252. link
  30. Patel, S.K.‡; Long, T.E.* “Preparation of Vinylglycines by Thermolysis of Homocysteine Sulfoxides,” Tetrahedron Lett. 2009, 50, 5067–5070. link
  • † Pharm.D. student       
  • ‡ M.S. or Ph.D. student
  • * Corresponding author        
From Ph.D. and Postdoctoral Studies
  1. Wencewicz, T.A.; Long, T.E.; Möllmann, U.; Miller, M.J.* “Trihydroxamate Siderophore Fluoroquinolone Conjugates are Selective Sideromycin Antibiotics that Target Staphylococcus aureus,” Bioconjugate Chem. 2013, 24, 473–486. link
  2. Wencewicz, T.A.; Möllmann, U.; Long, T.E.; Miller, M.J.* “Is Drug Release Necessary for Antimicrobial Activity of Siderophore-drug Conjugates? Syntheses and Biological Studies of the Naturally Occurring Salmycin “Trojan Horse” Antibiotics and Synthetic Desferridanoxamine-antibiotic Conjugates,” Biometals 2009, 22, 633–648. link
  3. Chen, D; Falsetti, S.C.; Frezza, M.; Milacic, V.; Kazi, A.; Cui, Q.C; Long, T.E.; Turos, E.; Dou, Q.* “Anti-tumor Activity of N-Thiolated β-Lactam Antibiotics,” Cancer Lett. 2008, 268, 63–69. link
  4. Revell, K.D.; Heldreth, B.; Long T.E.; Jang, S.; Turos, E.* “N-Thiolated β-Lactams: Studies on the Mode of Action and Identification of a Primary Cellular Target in Staphylococcus aureus,” Bioorg. Med. Chem. 2007, 15, 2453–2467. link
  5. Turos, E.*; Long, T.E.; Heldreth B.; Leslie, J.M.; Reddy, G.S.K.; Wang. Y.; Coates, C.; Konaklieva, M.; Dickey, S.; Lim, D.V.; Gonzalez, A.E.“N-Thiolated β-Lactams: A New Family of Anti-Bacillus Agents,” Bioorg. Med. Chem. Lett. 2006, 16, 2084–2090. link
  6. Heldreth B; Long T. E.; Jang, S.; Reddy, G.; Turos, E.*; Dickey, S.; Lim, D.V. “N-Thiolated β-Lactam Antibacterials: Effects of the N-Organothio Substituent on Anti-MRSA Activity,” Bioorg Med Chem. 2006, 14, 3775–3784. link
  7. Turos, E.*; Coates, C.M.; Shim, J.-Y.; Wang, Y.; Leslie J.M.; Long T. E.; Reddy, G.S.K.; Ortiz, A.; Culbreath, M.; Dickey, S.; Lim, D.V.; Alonso, E.; Gonzalez, J. “N-Methylthio β-Lactam Antibacterials: Effects of the C3/C4 Ring Substituents on Anti-MRSA Activity,” Bioorg. Med. Chem. 2005, 13, 6289–6308. link
  8. Kazi, A.; Hill, R.; Long, T.E.; Kuhn, D.J.; Turos, E.; Dou, Q.* “Novel N-Thiolated β-Lactam Antibiotics Selectively Induce Apoptosis in Human Tumor and Transformed, But Not Normal or Nontransformed cells,” Biochem. Pharmacol. 2004, 67, 365–374. link
  9. Carr, J.A.; Al-Azemi, T.F.; Long, T.E.; Shim, J.-Y.; Coates, C.M.; Turos, E.; Bisht, K.S.* “Lipase-Catalyzed Resolution of 4-Aryl-Substituted β-Lactams: Effect of Substitution on the 4-Aryl Ring,” Tetrahedron 2003, 59, 9147–9160. link
  10. Long, T.E.; Turos, E.*; Konaklieva, M.; Blum, A.L.; Amry, A.; Baker, E.A.; Suwandi, L.S.; McCain, M.D.; Rahman, M.; Dickey,S.; Lim, D.V. “Effect of Aryl Ring Fluorination on the Antibacterial Properties of C4 Aryl-Substituted N-Methylthio β-Lactams,” Bioorg. Med. Chem. 2003, 11, 1859–1863. link
  11. Long, T.E.* “Recent Progress Toward the Clinical Development of New Anti-MRSA Antibiotics,” IDrugs 2003, 6, 351–359. link
  12. Coates, C.; Long, T.E.; Turos, E*.; Dickey, S.; Lim, D.V. “N-Thiolated β-lactam Antibacterials: Defining the Role of Unsaturation in the C4 Side Chain,” Bioorg. Med. Chem. 2003, 11,193–196. link
  13. Smith, D.M.; Kazi, A.; Smith, L.; Long, T.E.; Heldreth, B.; Turos, E.; Dou, Q.P.* “A Novel β-Lactam Antibiotic Activates Tumor Cell Apoptotic Program by Inducing DNA Damage,” Mol. Pharmacol. 2002, 61, 1348–1358. link
  14. Turos, E.*; Long, T.E.; Konaklieva, M.I.; Coates, C.; Shim J.-Y.; Dickey, S.; Lim, D.V.; Cannons, A. “N-Thiolated β-Lactams: Novel Antibacterial Agents for Methicillin-Resistant Staphylococcus aureus,” Bioorg. Med. Chem. Lett. 2002, 12, 2229–2223. link
  15. Long, T.E.; Turos, E.* “N-Thiolated β-Lactams,” Curr. Med. Chem.: Anti-Infective Agents 2002, 1, 251–268. link
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