{"id":28,"date":"2021-01-07T22:38:32","date_gmt":"2021-01-07T22:38:32","guid":{"rendered":"https:\/\/mupages.marshall.edu\/sites\/longlab\/?page_id=28"},"modified":"2026-04-07T10:39:31","modified_gmt":"2026-04-07T14:39:31","slug":"publications","status":"publish","type":"page","link":"https:\/\/mupages.marshall.edu\/longlab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n
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  1. Karuturi, S.\u2021<\/sup>; Jobe, K.L.\u2021<\/sup>; Varney, M.E.; Hambuchen, M.D.; Amin, A.R.M.R.; Long, T.E. “Optimization of (Dithioperoxo)thiolate-Based Antifungal Agents for Triazole-Resistant Aspergillus Fumigatus<\/em>,” Pathogens<\/em> 2025<\/strong>, 14<\/em>, 878. link<\/a><\/li>\n\n\n\n
  2. Das, P.V.,\u2021<\/sup> Valentine, M.E., Long, T.E., Yu, H.D. “Attenuated Strains of Pseudomonas aeruginosa<\/em>\u202f: A Promising Cell Factory for Rhamnolipid Production,” Microb Biotechnol.<\/em> 2025<\/strong>, 18<\/em> (11). link<\/a><\/li>\n\n\n\n
  3. Long, T.E.; Naidu S.T.\u2021<\/sup>; Hissom E.G.\u2021<\/sup>; Meka Y.\u2021<\/sup>; Chavva H.; Brown K.C.; Valentine M.E.; Fan J.; Denvir J.; Primerano D.A.; Yu H.D.; Valentovic M.A. “Disulfiram Induces Redox Imbalance and Perturbations in Central Glucose Catabolism and Metal Homeostasis to Inhibit the Growth of Staphylococcus Aureus<\/em>,” Sci Rep<\/em>. 2025<\/strong>, 15<\/em>, 15658. link<\/a><\/li>\n\n\n\n
  4. Evans, S.E.\u2021<\/sup>; Valentine, M.E.; Gallimore, F.\u2021<\/sup>; Meka, Y.\u2021<\/sup>; Koehler, S.I.; Yu, H.D.; Valentovic, M.A.; Long, T.E. “Perturbations in the Gut Microbiome of C57BL\/6 Mice by the Sobriety Aid Antabuse\u00ae (Disulfiram),”. J Appl Microbiol.<\/em> 2025<\/strong>, 136<\/em>, 1:lxae305. link<\/a><\/li>\n\n\n\n
  5. Harrison, S.; Verratti, K.; Long, T.E.; Meka, Y.\u2021<\/sup>; Greytak, E.M.; Necciai, B.; Sozhamannan, S.; Sparklin, R. “Draft Genome Assemblies of Ciprofloxacin-resistant Derivatives of Bacillus cereus<\/em> Strain ATCC14579,” Microbiol Resour Announc<\/em>. 2025<\/strong>, 14:0:e00100-25. link<\/a><\/li>\n\n\n\n
  6. Chavva, H.; Meka, Y.\u2021<\/sup>; Long, T.E. “Antimicrobial Pharmacodynamics of Vancomycin and Disulfiram (Antabuse\u00ae) in Staphylococcus aureus,<\/em>” Front. Microbiol<\/em>. 2023<\/strong>, 13:1092257. link<\/a><\/li>\n\n\n\n
  7. Blume, L.\u2021<\/sup>; Long, T.E.; Turos, E. “Applications and Opportunities in Using Disulfides, Thiosulfinates, and Thiosulfonates as Antibacterials.” Int J Mol Sci.<\/em> 2023<\/strong>, 24,<\/em> 8659. link<\/a><\/li>\n\n\n\n
  8. Newton, E..; Starcovic, S.A.; Menze, M.; Konkle, M.E.; Long, T.E.; Hazlehurst, L.A.; Huber, J.D.; Robart, A.R.; Geldenhuys, W.J. “Development of a Fluorescence Screening Assay for Binding Partners of the Iron-sulfur Mitochondrial Protein MitoNEET,” Bioorg Med Chem Lett. <\/em>2023<\/strong>, 89:129310. link<\/a><\/li>\n\n\n\n
  9. Brown, K.C.; Modi, K.J., Light, R.S.; Cox, A.J.; Long, T.E.; Gadepalli, R.S.; Rimoldi, J.M.; Miles, S.L.; Rankin, G.; Valentovic, M.; Denning, K.L.; Tirona, M.T.; Finch, P.T.; Hess, J.A.; Dasgupta, P. “Anticancer Activity of Region B Capsaicin Analogs,” J Med Chem<\/em>. 2023<\/strong>, 66<\/em>, 7, 4294\u20134323. link<\/a><\/li>\n\n\n\n
  10. Shanholtzer, C.N.\u2020<\/sup>; Rice, C.\u2020<\/sup>; Watson, K.\u2020<\/sup>; Carreon ,H.\u2020<\/sup>; Long, T.E. \u201cEffect of Copper on the Antifungal Activity of Disulfiram (Antabuse\u00ae) in Fluconazole-resistant Candida<\/em> Strains,\u201d Med. Mycol.<\/em> 2022<\/strong>, 60<\/em>, myac016. link<\/a><\/li>\n\n\n\n
  11. Adeluola, A.A.\u2021<\/sup>; Bosomtwe, N.; Long, T.E.; Amin, A.R.M. R. “Context-dependent Activation of p53 Target Genes and Induction of Apoptosis by Actinomycin D in Aerodigestive Tract Cancers,” Apoptosis<\/em>, 2022<\/strong>, 27<\/em>, 342\u2013353. link<\/a><\/li>\n\n\n\n
  12. Lewis, A.D.\u2020<\/sup>; Riedel, T.M.\u2020<\/sup>; Kesler, M.B.A.\u2021<\/sup>; Varney, M.E.; Long, T.E. \u201cPharmacological Evaluation of Disulfiram Analogs as Antimicrobial Agents and Their Application as Inhibitors of FosB-Mediated Fosfomycin Resistance,\u201d J. Antibiot.<\/em> 2022<\/strong>, 75<\/em>, 146\u2013154. link<\/a><\/li>\n\n\n\n
  13. Custodio, M.; Sparks, J.; Long, T.E. \u201cDisulfiram: A Repurposed Drug in Preclinical and Clinical Development for the Treatment of Infectious Diseases,\u201d Anti-Infect. Agents<\/em> 2022<\/strong>, 20<\/em>, 34\u201345. link<\/a><\/li>\n\n\n\n
  14. Clay, T.B.; Orwig, K.W.; Stevens, R. A.\u2020<\/sup>; Davis, E.P.\u2020<\/sup>; Jennings, T.M.\u2020<\/sup>; Long, T.E.; Riley, B.L.; Hambuchen, M.B. \u201cCorrelation of MRSA Polymerase Chain Reaction (PCR) Wound Swab Testing and Wound Cultures in Skin and Soft Tissue Infections,\u201d Diagn. Microbiol. Infect. Dis<\/em>. 2021<\/strong>, 100<\/em>, 115389. link<\/a><\/li>\n\n\n\n
  15. Cabal, M.-P.; Long, T.E.; Turos E.; Garc\u00eda, A.-B.; Allen. J.L.; Budny, B.G.\u2021<\/sup>; Shaw, L.N. \u201cSpiropiperidyl Rifabutins: Expanded In Vitro<\/em> Testing Against ESKAPE Pathogens and Select Bacterial Biofilms,\u201d J. Antibiot. <\/em>2020<\/strong>, 868\u2013872. link<\/a><\/li>\n\n\n\n
  16. Moore, J.A.\u2020<\/sup>; Meakin, M.\u2020<\/sup>; Earl, M.A.\u2020<\/sup>; Kummer, T.M.\u2020<\/sup>; McAleer, J.M.; Long, T.E. \u201cEffects of Caspofungin, Tolcapone, and Other FDA-Approved Medications on MRSA Susceptibility to Vancomycin,\u201d J. Glob. Antimicrob. Resist.<\/em> 2020<\/strong>, 22<\/em>, 283\u2013289. link<\/a><\/li>\n\n\n\n
  17. Valentine, M.; Kirby, B.; Withers, T.R.; Johnson, S L.; Long, T.E.; Hao, Y.; Lam, J.; Niles, R.; Yu, H. “Generation of a Highly Attenuated Strain of Pseudomonas aeruginosa<\/em> for Commercial Production of Alginate,” Microb. Biotechnol<\/em>. 2020<\/strong>, 13<\/em>, 162\u2013175. link<\/a><\/li>\n\n\n\n
  18. Geldenhuys, W.J.; Long, T.E.; Saralkar, P.; Iwasaki, T.; Nu\u00f1ez, R.A.; Nair, R.R.; Konkle, M.E.; Menze, M.A.; Pinti, M.V.; Hollander, J.M.; Hazlehurst, L.A.;  Robart, A.R.* “Crystal Structure of the Mitochondrial Protein MitoNEET Bound to a Benze-sulfonide Ligand,” Commun. Chem. <\/em>2019<\/strong>, 2<\/em>, doi:10.1038\/s42004-019-0172-x. link<\/a><\/li>\n\n\n\n
  19. Kirby, B.; Ahmar, R.A.\u2021<\/sup>; Withers, T.R.; Valentine, M.; Valentovic, M.; Long, T.E.; Gaskins, J.; Yu, H. \u201cEfficacy of Aerosolized Rifaximin Versus Tobramycin for the Treatment of Pseudomonas aeruginosa<\/em> Pneumonia in Mice,\u201d Antimicrob. Agents Chemother<\/em>. 2019<\/strong>, 63<\/em>, pii: e02341\u201318; doi: 10.1128\/AAC.02341-18. link<\/a><\/li>\n\n\n\n
  20. Geldenhuys, W.J.; Skolik, R.; Konkle, M.E.; Menze, M.A.; Long, T.E.; Robart, A.E.* \u201cBinding of Thiazolidinediones to the Endoplasmic Reticulum Protein Nutrient-Autophagy Factor 1,\u201d Bioorg. Med. Chem. Lett<\/em>. 2019<\/strong>, 29<\/em>, 901\u2013904. link<\/a><\/li>\n\n\n\n
  21. Frazier, K.R.\u2020<\/sup>; Moore, J.A.\u2020<\/sup>; Long, T.E. \u201cAntibacterial Activity of Disulfiram and its Metabolites,” J. Applied Microbiol<\/em>. 2019<\/strong>, 126<\/em>, 79\u201386. link<\/a><\/li>\n\n\n\n
  22. Sheppard, J.G.\u2020<\/sup>; Frazier, K.R.\u2020<\/sup>; Saralkar, P.; Hossain, M.F.; Geldenhuy,s W.; Long, T.E. “Disulfiram-based Disulfides as Narrow-spectrum Antibacterial Agents,” Bioorg. Med. Chem. Lett<\/em>. 2018<\/strong>, 28<\/em>, 1298\u20131302. link<\/a><\/li>\n\n\n\n
  23. Sheppard, J.G.\u2020<\/sup>; McAleer, J.P.; Saralkar, P.; Geldenhuys, W.J.; Long, T.E. “Allicin-inspired Pyridyl Disulfides as Antimicrobial Agents for Multidrug-resistant Staphylococcus aureus<\/em>,” Eur. J. Med. Chem.<\/em> 2018<\/strong>, 143<\/em>, 1185\u20131195. link<\/a><\/li>\n\n\n\n
  24. Long T.E. \u201cRepurposing Thiram and Disulfiram as Antibacterial Agents for Multi-drug Resistant Staphylococcus aureus<\/em> Infections\u201d. Antimicrob. Agents Chemother<\/em>. 2017<\/strong>, 61:e00898-17. link<\/a><\/li>\n\n\n\n
  25. Sheppard, J.G.\u2020<\/sup>; Long, T.E. \u201cAllicin-inspired Thiolated Fluoroquinolones as Antibacterials Against ESKAPE Pathogens,\u201d Bioorg. Med. Chem. Lett.<\/em> 2016<\/strong>, 26<\/em>,5545\u20135549. link<\/a><\/li>\n\n\n\n
  26. Slayton, E.T.\u2020<\/sup>; Hay, A.S.; Babcock, C K.; Long, T.E. \u201cNew Antibiotics in Clinical Trials for Clostridium Difficile<\/em>,\u201d Expert Rev. Anti. Infect. Ther<\/em>. 2016<\/strong>, 14<\/em>, 789\u2013800. link<\/a><\/li>\n\n\n\n
  27. Long, T.E.; Keding, L.C.\u2021<\/sup>; Lewis, D.\u2020<\/sup>; Anstead, M.I.; Withers, T.R.; Yu, H.D. \u201cAnionic Fluoroquinolones as Antibacterials Against Biofilm-producing Pseudomonas aeruginosa<\/em>,\u201d Bioorg. Med. Chem. Lett.<\/em> 2016<\/strong>, 26<\/em>, 1305\u20131309. link<\/a><\/li>\n\n\n\n
  28. Long, T.E.; Williams, J. \u201cCephalosporins Currently in Early Clinical trials for the Treatment of Bacterial Infections,\u201d Expert Opin. Investig. Drugs<\/em> 2014<\/strong>, 23<\/em>, 1375\u20131387. link<\/a><\/li>\n\n\n\n
  29. Lu, X.\u2021<\/sup>; Altharawi, A.\u2021<\/sup>; Gut, J.; Rosenthal, P.J.; Long, T.E. “1,4-Naphthoquinone Cations as Antiplasmodial Agents: Hydroxy-, Acyloxy-, and Alkoxy-Substituted Analogs,” ACS Med. Chem. Lett.<\/em> 2012<\/strong>, 3<\/em>, 1029\u20131033. link<\/a><\/li>\n\n\n\n
  30. Lu, X.\u2021<\/sup>; Altharawi, A.\u2021<\/sup>; Hansen, E.N.\u2020<\/sup>; Long, T.E. “Phase-Transfer Catalysts in the O-Alkylation of 2-Hydroxynaphthoquinones,” Synthesis<\/em> 2012<\/strong>, 44<\/em>, 3225\u20133230. link<\/a><\/li>\n\n\n\n
  31. Mock, J.\u2021<\/sup>; N; Taliaferro, J.P.\u2021<\/sup>; Lu, X.\u2021<\/sup>; Patel, S.K.\u2021<\/sup>; Cummings, B.S.; Long, T.E. “Haloenol Pyranones and Morpholinones as Antineoplastic Agents of Prostate Cancer,” Bioorg. Med. Chem. Lett.<\/em> 2012<\/strong>, 22<\/em> 4854\u20134858. link<\/a><\/li>\n\n\n\n
  32. Long, T.E.; Lu, X.\u2021<\/sup>; Galizzi, M.; Docampo, R.; Gut, J.; Rosenthal, P.J. “Phosphonium Lipocations as Antiparasitic Agents,” Bioorg. Med. Chem. Lett.<\/em> 2012<\/strong>, 22<\/em>, 2976\u20132979. link<\/a><\/li>\n\n\n\n
  33. Lu, X.\u2021<\/sup>; Long, T. E. “Asymmetric Synthesis of Monocyclic \u03b2-Lactams from L-Cysteine Using Photochemistry,” Tetrahedron Lett. <\/em>2011,<\/strong> 52<\/em>, 5051\u20135054. link<\/a><\/li>\n\n\n\n
  34. Lu, X.\u2021<\/sup>; Long, T.E. \u201co<\/em>-Nitrophenyl Sulfoxides: Efficient Precursors for the Mild Preparation of Alkenes,\u201d J. Org. Chem. <\/em>2010<\/strong>, 75<\/em>, 249\u2013252. link<\/a><\/li>\n\n\n\n
  35. Patel, S.K.\u2021<\/sup>; Long, T.E. \u201cPreparation of Vinylglycines by Thermolysis of Homocysteine Sulfoxides,\u201d Tetrahedron Lett. <\/em>2009,<\/strong> 50<\/em>, 5067\u20135070. link<\/a><\/li>\n<\/ol>\n\n\n\n